The bases will close from November to March due to Covid-19 restrictions.
The airline made the announcement this morning along with the closure of its base in Toulouse in France and a reduction of its winter schedule.
In response to the news, the Department of Transport says that government has agreed to adopt the EU "traffic light" system for international travel, with a decision on implementation expected next week.
But CEO of Ryanair Eddie Wilson says the decision is coming too late:
Cork Airport say they hope Ryanair will return to their base here before the start of next summer
The budget airline have had a base in Cork since 2005 and fly to 24 airports in eight countries from the airport.
Management say they have done everything in their power to keep the base and will continue to work towards its return before the summer.
Speaking to RedFM News, Managing Director of Cork Airport Niall McCarthy says government support will be vital for the airport's recovery:
