Over 200 medicines are now unavailable to Irish patients, which includes treatment for chest infections, strep-throat, pneumonia and blood pressure.
The analysis compiled by industry experts also found 11 of these medicines are deemed critical by the World Health Organisation.
The analysis carried out by Azure Pharmaceuticals found penicillin-based antibiotics used to treat bacterial infections are currently 'unavailable from any supplier or source' in Ireland.
It included Amoxicillin and Penicillin, as well as Cefalexin - an anti-biotic commonly used to treat respiratory infections.
The analysis based on data from the HP-RA also showed a major shortage of over-the-counter cough syrups for both adults and children, Sprays for sore throats, dissolvable paracetamol powder, and aspirin.
In total, 212 medicines are currently unavailable in the country - up from 25 month.
40 per cent the over 200 medicines currently out of stock were found to have just one supplier.