Another person is critical after the collision involving a lorry and two cars in Castleblaney which happened on the N2 at around 18:15 yesterday evening.
A man and woman in their 60s who were in one of the cars were pronounced dead at the scene.
A woman in her 60s who was a passenger in the second car was taken to Our Lady of Lourdes Drogheda to be treated for her injuries, which are critical.
Gardaí are appealing for witnesses to come forward.